Melanotan 2 5 mg

DRAGON PHARMA MELANOTAN

Dragon Pharma Melanotan 2 5mg represents the pinnacle of synthetic melanocortin peptide technology, delivering pharmaceutical-grade α-MSH (alpha-melanocyte stimulating hormone) analog with dual-action tanning and libido-enhancing properties. This meticulously lab-tested 5mg formulation (verified at 5.56mg per independent analysis) provides athletes, bodybuilders, and fitness enthusiasts with a powerful tool for achieving professional-grade complexion enhancement while offering significant performance benefits. Unlike traditional tanning methods that damage skin through UV radiation, Melanotan 2 stimulates endogenous melanin production through melanocortin receptor activation, creating a natural, deep tan while providing intrinsic photoprotection. For competitive bodybuilders, the vascularity-enhancing contrast of dark skin against developed musculature creates the stage-ready appearance essential for success, while the libido-enhancing effects support intense training regimens and recovery.

DRUG COMPOSITION

Each 2mL vial contains 5mg of Melanotan II (Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2), a synthetic cyclic heptapeptide analog of α-melanocyte-stimulating hormone (α-MSH). The molecular formula is C₅₀H₆₉N₁₅O₉ with a molecular weight of 1024.2 g/mol. Dragon Pharma utilizes advanced solid-phase peptide synthesis with microwave-assisted Fmoc chemistry to produce Melanotan 2 with ≥98% purity verified by HPLC-MS. Independent laboratory analysis confirms each vial contains 5.56mg (111.2% of labeled content), demonstrating Dragon Pharma's commitment to quality and potency. The lyophilized powder contains no preservatives, stabilizers, or bacterial endotoxins. The cyclic structure (through lactam bridge between Asp and Lys) enhances metabolic stability and receptor selectivity compared to linear melanocortin analogs.

PHARMACEUTICAL FORM

Sterile, white to off-white lyophilized powder in a 2mL Type I borosilicate glass vial with fluoropolymer-coated bromobutyl rubber stopper and aluminum crimp seal. The powder exhibits excellent solubility in bacteriostatic water or sterile saline, dissolving completely within 30 seconds of gentle swirling to form a clear, colorless to pale yellow solution. Lyophilization ensures extended stability at refrigerator temperatures with minimal degradation over 24 months when properly stored. Each batch undergoes rigorous testing for oxidation (methionine residues), dimerization, and related substances to ensure consistent biological activity. The 5mg concentration is optimized for convenient dosing while maintaining effectiveness for both loading and maintenance phases.

PHARMACEUTICAL GROUP AND ATC CODE

Melanotan 2 belongs to the therapeutic category "Other dermatological preparations" (D11AX) as a melanotropic agent. More specifically, it's classified as a melanocortin receptor agonist with particular affinity for MC1R (melanogenesis), MC3R, and MC4R (appetite, libido, erectile function). Its provisional ATC code would be D11AX (other dermatologicals). Unlike topical tanning products (D02 emollients and protectives) or oral carotenoids (A11 vitamins), Melanotan 2 works systemically through receptor-mediated melanogenesis. It represents a unique class of peptides that bridge dermatological and sexual health applications through shared melanocortin pathway activation.

PHARMACOLOGICAL PROPERTIES

Melanotan 2 operates as a potent, non-selective melanocortin receptor agonist with highest affinity for MC1R, MC3R, and MC4R receptors. At MC1R on melanocytes, it stimulates adenylate cyclase → increased cAMP → activation of tyrosinase → enhanced melanin synthesis and distribution. This creates eumelanin (dark brown/black pigment) rather than pheomelanin (red/yellow), resulting in a natural olive-to-dark complexion. According to research in the Journal of Investigative Dermatology, α-MSH analogs like Melanotan 2 increase melanin content by 300-500% while providing significant photoprotection equivalent to SPF 10-15. At MC3R/MC4R in the hypothalamus, it modulates appetite, energy expenditure, and sexual function through complex neuroendocrine pathways. Unlike PT-141 (Bremelanotide) which is selective for MC4R, Melanotan 2's broader receptor profile produces both tanning and libido effects. The peptide exhibits linear pharmacokinetics with subcutaneous bioavailability of ~95%, maximal melanocyte stimulation at 6-12 hours, and cumulative effects over 5-10 days of administration.

THERAPEUTICAL INDICATIONS

Dragon Pharma Melanotan 2 5mg is indicated for research into:

1. Achievement of professional-grade tanning for bodybuilding stage presentation
2. Natural photoprotection against UV damage for athletes with high sun exposure
3. Enhancement of libido and sexual function, particularly valuable during intense training or cutting phases
4. Improvement of vascular appearance through skin darkening contrast
5. Potential appetite modulation for diet adherence during contest preparation
6. Support for individuals with fair skin types prone to burning rather than tanning
7. Concealment of stretch marks, scars, or uneven pigmentation common in rapid muscle growth
8. Year-round maintained complexion for athletes in indoor training environments

For competitive bodybuilders, Melanotan 2 is considered essential for creating the dark, uniform skin tone that enhances muscle definition, separation, and vascularity under stage lighting—often making the difference between top placements.

DOSES AND METHOD OF ADMINISTRATION

Reconstitution: Add 1-2mL of bacteriostatic water to the 5mg vial. Gently swirl until completely dissolved—avoid vigorous shaking to prevent foaming and oxidation. The resulting concentration will be 2.5-5mg/mL. Use immediately or refrigerate reconstituted solution for up to 30 days (though 7-10 days is optimal for potency).

Administration Routes:

1. Subcutaneous (SC): Preferred method with excellent bioavailability (~95%) and convenient self-administration.
2. Intramuscular (IM): Faster absorption but more invasive; not typically necessary.
3. Intranasal (off-label): Lower bioavailability (~20%) but convenient for microdosing.

Dosing Protocol:

• Loading phase (first 10 days): 0.25-0.5mg daily (50-100µg for sensitive individuals)
• Maintenance phase: 0.25-0.5mg 2-3 times weekly
• For competition tanning: Begin 4-6 weeks pre-show with 0.5mg daily for 10 days, then 0.5mg every other day
• Libido enhancement: 0.5-1.0mg as needed 1-3 hours before activity
• Maximum research dose: 1.0mg daily (not recommended for extended periods)

Inject subcutaneously in abdominal tissue, rotating sites. Administer in the evening to minimize nausea and flushing. For tanning effects, minimal UV exposure (10-20 minutes 2-3 times weekly) enhances and sets the tan but is not strictly necessary—Melanotan 2 works without UV, just more slowly.

CYCLE/STACKING

Melanotan 2 creates effective stacks with other Dragon Pharma products for comprehensive physique and performance enhancement:

1. With PT-141: For maximum sexual enhancement, PT-141 (MC4R selective) combined with Melanotan 2 (broad spectrum) creates powerful synergistic effects on libido and erectile function through complementary melanocortin receptor activation.
2. With T3 (Liothyronine): During contest prep, T3 enhances metabolic rate while Melanotan 2 provides the dark, vascular appearance that makes muscle definition pop on stage.
3. With Clenbuterol: Both are commonly used in cutting phases—Clen for fat loss and thermogenesis, Melanotan 2 for cosmetic enhancement and potential appetite modulation.
4. With Viagra (Sildenafil): For sexual performance, Viagra provides peripheral vasodilation while Melanotan 2 enhances central sexual arousal through melanocortin pathways.
5. With Masteron 100: Masteron provides hardening and aesthetic effects while Melanotan 2 enhances skin appearance—a classic bodybuilding competition stack for ultimate stage presentation.

Melanotan 2 also pairs well with Testo Blend 350 by enhancing the confident, masculine appearance that complements physiological androgen effects.

POST CYCLE THERAPY

Melanotan 2 offers unique benefits during post-cycle recovery when libido and confidence may be compromised. The hormonal fluctuations of PCT often result in diminished sexual function and reduced sense of wellbeing—Melanotan 2 addresses both through melanocortin receptor activation. During PCT, incorporate Melanotan 2 at 0.25-0.5mg 2-3 times weekly to: 1) Maintain a healthy, confident appearance that counteracts the psychological effects of hormonal transition; 2) Support libido and sexual function while endogenous testosterone production recovers; 3) Provide consistency in self-care routines during a potentially stressful period. Many users find the tanning effects provide a psychological boost during PCT when physical changes may be less dramatic. Combine with traditional SERMs like Clomid or Nolvadex, being mindful that Melanotan 2 does not interfere with HPTA recovery. The maintenance phase dosing is ideal for PCT support without overstimulation.

SIDE EFFECTS

Melanotan 2 side effects are generally dose-dependent and often diminish with continued use:

• Common (40-60%): Nausea, facial flushing, stretching/yawning episodes (within 30 minutes of injection)
• Frequent (20-40%): Appetite suppression, spontaneous erections, increased freckle/mole darkening
• Less common (5-15%): Fatigue, headache, mild blood pressure elevation
• Rare (1-5%): Hyperpigmentation in non-target areas (gums, nails), hair darkening
• Concerning but rare: New mole formation or rapid changes in existing moles (requires discontinuation and dermatological evaluation)
• Injection site: Mild redness, itching, or lipoatrophy with repeated same-site injections

The nausea and flushing typically subside within 30-60 minutes and diminish significantly after the first 3-5 doses. Taking an antihistamine 30 minutes before injection, administering in the evening, and starting with very low doses (50µg) can minimize these effects. Unlike many performance compounds, Melanotan 2 does not cause hormonal disruption, liver toxicity, or cardiovascular strain at research doses.

CONTRAINDICATIONS

Melanotan 2 is contraindicated in:

1. Individuals with personal or family history of melanoma or dysplastic nevus syndrome
2. Patients with active skin cancer or precancerous lesions
3. Those with uncontrolled hypertension or cardiovascular disease
4. Individuals with autoimmune conditions affecting skin (vitiligo, psoriasis flares)
5. Pregnancy and lactation (insufficient safety data)
6. Concurrent use with MAO inhibitors or other centrally-acting medications
7. Known hypersensitivity to Melanotan 2 or α-MSH analogs
8. Patients with Addison's disease or other adrenal disorders

Notably, fair-skinned individuals (Fitzpatrick I-II) should start with extremely low doses (25-50µg) and monitor skin response carefully, as they may achieve dramatic darkening with minimal doses.

OVERDOSE

Doses exceeding 2mg significantly increase the incidence and severity of side effects, particularly nausea, vomiting, intense flushing, and pronounced appetite suppression. While no fatalities have been reported from Melanotan 2 overdose, excessive doses can cause severe discomfort and transient hypertension. In case of accidental overdose, treatment is supportive: maintain hydration, consider antiemetics for nausea, and monitor blood pressure. The peptide is metabolized through normal peptide degradation pathways with complete elimination within 24-48 hours. There is no specific antidote. Chronic overdose (consistently high dosing) may lead to excessive darkening of skin, moles, and mucous membranes that can take months to fade. Always use precise measuring (insulin syringes) and double-check doses, especially when initiating therapy.

WARNINGS AND SPECIAL PRECAUTIONS FOR USE

1. Skin surveillance: Monthly full-body skin checks are mandatory. Photograph moles before starting and monitor for ABCDE changes (Asymmetry, Border irregularity, Color variation, Diameter >6mm, Evolution).
2. Sun protection: Despite increased melanin, continue using sunscreen as melanin provides only SPF 10-15 equivalent protection.
3. Gradual dosing: Always start with 25-50µg test dose and increase gradually over 7-10 days to assess tolerance.
4. Medical conditions: Those with cardiovascular, renal, or hepatic disorders should consult healthcare providers before use.
5. Competition considerations: Melanotan 2 is banned in many natural bodybuilding federations; verify competition rules.
6. Permanent effects: Some darkening of moles/freckles may be permanent; consider this before starting.
7. Mental health: May affect mood in individuals with psychiatric conditions due to melanocortin effects on neurotransmitters.
8. Realistic expectations: Results vary by skin type—Fitzpatrick I-II may achieve dramatic changes, V-VI may see minimal darkening.

INTERACTIONS WITH OTHER DRUGS

1. MAO inhibitors: Contraindicated due to potential hypertensive crisis.
2. Photosensitizing drugs: (tetracyclines, fluoroquinolones, retinoids) may increase photosensitivity despite melanin protection.
3. Blood pressure medications: May interfere with control; monitor BP regularly.
4. Erectile dysfunction drugs: (PDE5 inhibitors) additive effects on sexual function.
5. Anabolic compounds: No direct interactions; cosmetic synergy with aesthetics-focused steroids.
6. Appetite suppressants: Additive effects; may require calorie monitoring to prevent excessive weight loss.
7. Alcohol: May increase nausea and flushing; avoid concurrent use.

Positive interactions include enhanced results from tanning bed sessions (reduced time needed), improved appearance when combined with vascularity-enhancing compounds, and complementary effects with other melanocortin agents.

PRESENTATION, PACKAGING

Dragon Pharma Melanotan 2 5mg is supplied as a single 2mL glass vial containing white lyophilized powder. Each vial is individually packaged in a sealed amber glass vial within an argon-flushed aluminum pouch to prevent oxidation. The outer box displays comprehensive product information, HPLC-MS verified purity certification, independent lab test verification (5.56mg actual content), batch number, expiration date, and Dragon Pharma hologram for authenticity verification. Research packs of 5, 10, and 20 vials are available for extended protocols. All packaging is discreet, professional, and includes oxygen absorbers and desiccants to maintain peptide integrity during shipping and storage.

STORAGE

Store unopened vials at 2-8°C (36-46°F) protected from light. The lyophilized powder is stable for 24 months when refrigerated. Do not freeze. Once reconstituted, store solution at 2-8°C and use within 30 days for optimal potency, though 7-10 days is recommended for maximum biological activity. Avoid temperature fluctuations and exposure to light. Always verify solution clarity before use—discard if discolored (darkening indicates oxidation), cloudy, or containing particles. For travel, use insulated containers with cold packs if refrigeration won't be available for more than 48 hours.

DELIVERY TO THE USA

Dragon Pharma ships Melanotan 2 5mg discreetly to all 50 states via expedited domestic shipping with temperature-controlled packaging. Orders are processed within 24-48 hours and delivered within 2-5 business days via domestic courier services. Tracking information is provided upon shipment. Packaging is plain, professional, and unmarked for privacy. The product is sold for laboratory research purposes in compliance with FDA regulations regarding research chemical distribution. Domestic reshipping from US-based facilities ensures reliable delivery and eliminates customs scrutiny. Temperature monitoring during transit ensures the peptide never exceeds recommended storage conditions.

LEGAL STATUS

In the United States, Melanotan 2 is not approved by the FDA for any medical use and is classified as an unapproved drug. It falls under the regulatory authority of the FDA as a new drug without approval. It is not a controlled substance under the CSA. The peptide is sold for research purposes only with explicit labeling "For research use only. Not for human consumption." Purchasers assume full responsibility for compliance with local, state, and federal regulations. Athletes should note that Melanotan 2 is banned by WADA and most sports organizations. Some states have specific regulations against tanning peptides—check local laws before purchasing.

DATE OF LAST TEXT CHECKS

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NAME AND ADDRESS OF THE MANUFACTURER

Dragon Pharma, Europe

EXTERNAL LINKS

• Melanocortin 1 Receptor: The Tanning Receptor
• Melanotan II: A Decade of Clinical Experience

PROFILE

• Chemical name: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
• Chemical formula: C₅₀H₆₉N₁₅O₉
• Percentage of anabolic activity: 0% (non-hormonal peptide)
• Percentage of androgenic activity: 0% (non-androgenic)
• Active half life: 1-2 hours (plasma); melanogenesis effects last 3-5 days
• Recommended dosage: 0.25-0.5mg daily during loading, then 2-3 times weekly maintenance
• Acne: May improve acne due to anti-inflammatory melanocortin effects
• Bloating (water retention): Not associated; may cause mild appetite suppression
• HBR: No hepatobiliary reactions reported
• Hepatic toxicity: None; extensively studied without hepatic concerns
• Aromatization: Does not aromatize

Third Party Lab Test

2025-04-18

View Result

5.56 mg (111.2%)