Sibutramine

DRAGON PHARMA SIBUTRAMINE

Sibutramine is a centrally acting serotonin-norepinephrine reuptake inhibitor (SNRI) that was once used as an appetite suppressant for weight management. It works by affecting neurotransmitters in the brain to induce a feeling of fullness, promoting weight loss.

DRUG COMPOSITION

The primary composition of sibutramine includes the active ingredient sibutramine hydrochloride monohydrate, which modulates serotonin and norepinephrine levels in the central nervous system.

PHARMACEUTICAL FORM

Sibutramine is commonly available in oral tablet form, with variations in dosage strengths. The tabletsare designed for oral administration with water.

PHARMACEUTICAL GROUP AND ATC CODE

Sibutramine belongs to the therapeutic group of antiobesity preparations, excluding diet products (ATC code: A08AA10).

PHARMACOLOGICAL PROPERTIES

As an SNRI, sibutramine increases serotonin and norepinephrine levels in the synaptic cleft, promoting a sense of satiety and reducing appetite. This mechanism aids in weight loss by limiting food intake.

PROFILE

• Chemical name: BTS-54524
• Chemical formula: C17H26ClN
• Percentage of anabolic activity: Not a steroid
• Percentage of androgenic activity: Not a steroid
• Active half life: 1 hour
• Recommended dosage: 20 mg/day
• Acne: no
• Bloating (water retention): no
• HBR: no
• Hepatic toxicity: very low
• Aromatization: no

THERAPEUTICAL INDICATIONS

Sibutramine was indicated for the management of obesity, especially in individuals with associated risk factors like type 2 diabetes or dyslipidemia. However, it has been withdrawn from many markets due to safety concerns.

DOSES AND METHOD OF ADMINISTRATION

Dosage recommendations for sibutramine varied, but it was typically administered once daily, with or without food. The specific dose depended on individual patient response and tolerance.

CYCLE/STACKING

Sibutramine does not follow a traditional cycling pattern like some performance-enhancing substances. Instead, it was used as a chronic treatment until weight loss goals were achieved.

POST CYCLE THERAPY

As sibutramine was not used in cycling patterns common to anabolic steroids, there is no standard post-cycle therapy associated with its use.

SIDE EFFECTS

Common side effects of sibutramine include dry mouth, insomnia, constipation, and increased heart rate. Serious side effects may include elevated blood pressure and an increased risk of cardiovascular events.

CONTRAINDICATIONS

Sibutramine is contraindicated in individuals with a history of coronary artery disease, congestive heart failure, arrhythmias, or stroke. It is also not recommended for patients with severe hepatic or renal impairment.

OVERDOSE

Overdose of sibutramine may lead to symptoms such as increased blood pressure, tachycardia, and serotonin syndrome. Immediate medical attention is necessary in cases of suspected overdose.

WARNINGS AND SPECIAL PRECAUTIONS FOR USE:

Sibutramine use was associated with an increased risk of cardiovascular events, and its use should be carefully considered in individuals with pre-existing cardiovascular conditions. Regular monitoring of blood pressure and heart rate is advised during treatment.

INTERACTIONS WITH OTHER DRUGS

Sibutramine may interact with other medications, particularly those affecting serotonin levels. It is crucial for healthcare providers to be aware of all medications taken by the patient to avoid potential adverse reactions.

PRESENTATION, PACKAGING

100 tablets in sachet.

STORAGE

Sibutramine capsules should be stored in a cool, dry place, away from direct sunlight and moisture. It should be kept out of reach of children.

DELIVERY TO THE USA

Sibutramine is available for secure and discreet delivery to the USA through authorized supplier - Steroid.biz.

LEGAL STATUS

Sibutramine has been banned or withdrawn from many markets due to safety concerns, and its use is not recommended. Individuals should adhere to regulatory guidelines and consult healthcare professionals for weight management alternatives.

DATE OF LAST TEXT CHECKS

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NAME AND ADDRESS OF THE MANUFACTURER

Dragon Pharma
Europe

EXTERNAL LINKS

• Sibutramine Wiki, wikipedia.org
• Sibutramine Uses, Side Effects & Warnings, drugs.com
• Sibutramine - LiverTox - NCBI Bookshelf, ncbi.nlm.nih.gov.